Afrezza®

If you’re struggling with blood sugar control at mealtime, it’s time to consider a different option.

Afrezza®, the only ultra rapid-acting inhaled insulin, delivers glucose management in the moment for adults living with type 1 or type 2 diabetes

With the Afrezza® Savings Card, eligible commercially insured patients may pay as little as $15 per month.*

$45.00 / Physician Visit REQUEST PHYSICIAN VISIT

 

If you do not have prescription drug coverage, your insurance does not cover Afrezza®, or you cannot afford Afrezza®, eligible cash-paying patients may be able to obtain Afrezza® for as little as $99/month**

Please see Important Safety Information, including BOXED WARNING for Afrezza® below or by clicking here.

  • about-banner-placeholder

    No planning. No waiting. No needlesticks.

    Inhale your insulin right when food arrives, and Afrezza® will start lowering your blood sugar rapidly.

    By inhaling your insulin, you can save up to 1,000 needlesticks per year.*

    *Based on an estimation of approximately 3 meals per day, for a total of 1,095 possible mealtime injections per year.

  • about-banner-placeholder

    Discover management in the moment.

    Afrezza® is a needle-free mealtime insulin for people living with type 1 or type 2 diabetes.

    Afrezza® has proven mealtime control in studies of more than 3,000 people with both type 1 and type 2 diabetes.

    Talk to a doctor to see if Afrezza® may be right for you.

  • about-banner-placeholder

    Why inhale your insulin?

    Afrezza® is available in 4-, 8-, and 12-unit color-coded cartridges. The insulin is breathed through your lungs using the oral inhaler.

    Delivering the insulin over the large surface area of the lungs allows for ultra-rapid absorption.

  • about-banner-placeholder

    Fast in. Fast out. Fits your lifestyle.

    Once inhaled, Afrezza® starts lowering your blood sugar in about 12 minutes, and stops lowering your blood sugar in 1.5 – 3 hours.*

    This gives you the flexibility to inhale your insulin when you are ready to eat, so you can be spontaneous and still in control.

    *For the 4-unit and 12-unit cartridges, respectively.

Footnotes

    *This offer is not valid for patients receiving prescription reimbursement under any federal-, state-, or government-funded healthcare program, such as Medicare, Medicare Advantage, Medicare Part D, Medicaid, Medigap, Veterans Affairs (VA), the Department of Defense (DOD), or TRICARE, or where prohibited by law. Maximum benefit limitations and other restrictions apply. Click here for complete program terms and conditions.

    **MannKind also offers a direct purchase program. You may be eligible to get Afrezza® for as little as $99/month. For more information, and to see full terms and conditions, click here.

Important Safety Information

 

WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT AFREZZA®?

Afrezza® can cause serious side effects, including:

Sudden lung problems (bronchospasms). Do not use Afrezza® if you have long-term (chronic)
lung problems such as asthma or chronic obstructive pulmonary disease (COPD).
 Before starting Afrezza®, your healthcare provider will give you a breathing test to check how your lungs are working.

WHAT IS AFREZZA®?

  • • Afrezza® is a man-made insulin that is breathed-in through your lungs (inhaled) and is used to control high blood sugar in adults with diabetes mellitus.
  • • Afrezza® is not for use in place of long-acting insulin. Afrezza® must be used with long-acting insulin in people who have type 1 diabetes mellitus.
  • • Afrezza® is not for use to treat diabetic ketoacidosis.
  • • It is not known if Afrezza® is safe and effective for use in people who smoke. Afrezza® is not for use in people who smoke or have recently stopped smoking (less than 6 months).
  • • It is not known if Afrezza® is safe and effective in children under 18 years of age.

WHO SHOULD NOT USE AFREZZA®?

Do not use Afrezza® if you:

  • • Have chronic lung problems such as asthma or COPD.
  • • Are allergic to regular human insulin or any of the ingredients in Afrezza®. See the end of this Medication Guide for a complete list of ingredients in Afrezza®.

WHAT SHOULD I TELL MY HEALTHCARE PROVIDER BEFORE USING AFREZZA®?

Before using Afrezza®, tell your healthcare provider about all your medical conditions, including if you:

  • • Have lung problems such as asthma or COPD
  • • Have or have had lung cancer
  • • Are using any inhaled medications
  • • Smoke or have recently stopped smoking
  • • Have kidney or liver problems
  • • Are pregnant, planning to become pregnant, or are breastfeeding. Afrezza® may harm your unborn or breastfeeding baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins or herbal supplements.

Before you start using Afrezza®, talk to your healthcare provider about low blood sugar and how to manage it.

HOW SHOULD I USE AFREZZA®?

  • • Read the detailed Instructions for Use that comes with your Afrezza®.
  • • Take Afrezza® exactly as your healthcare provider tells you to. Your healthcare provider should tell you how much Afrezza® to use and when to use it.
  • • Know the strength of Afrezza® you use. Do not change the amount of Afrezza® you use unless your healthcare provider tells you to.
  • • Take Afrezza® at the beginning of your meal.
  • Check your blood sugar levels. Ask your healthcare provider what your blood sugar should be and when you should check your blood sugar levels.
  • Afrezza® and all medicines out of the reach of children.

YOUR DOSE OF AFREZZA® MAY NEED TO CHANGE BECAUSE OF:

  • • Change in level of physical activity or exercise, weight gain or loss, increased stress, illness, change in diet, or because of other medicines you take.

WHAT SHOULD I AVOID WHILE USING AFREZZA®?

While using Afrezza® do not:

  • • Drive or operate heavy machinery, until you know how Afrezza® affects you.
  • • Drink alcohol or use over-the-counter medicines that contain alcohol.
  • • Smoke.

WHAT ARE THE POSSIBLE SIDE EFFECTS OF AFREZZA®?

Afrezza® may cause serious side effects that can lead to death, including:

See “What is the most important information I should know about Afrezza®?” at the top of this page.

  • Low blood sugar (hypoglycemia). Signs and symptoms that may indicate low blood sugar include:
    • Dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability or mood change, hunger.
  • Decreased lung function. Your healthcare provider should check how your lungs are working before you start using Afrezza®, 6 months after you start using it and yearly after that.
  • Lung cancer. In studies of Afrezza® in people with diabetes, lung cancer occurred in a few more people who were taking Afrezza® than in people who were taking other diabetes medications. There were too few cases to know if lung cancer was related to Afrezza®. If you have lung cancer, you and your healthcare provider should decide if you should use Afrezza®.
  • Diabetic ketoacidosis. Talk to your healthcare provider if you have an illness. Your Afrezza® dose or how often you check your blood sugar may need to be changed.
  • Severe allergic reaction (whole body reaction). Get medical help right away if you have any of these signs or symptoms of a severe allergic reaction:
    • A rash over your whole body, trouble breathing, a fast heartbeat, or sweating.
  • Low potassium in your blood (hypokalemia).
  • Heart failure. Taking certain diabetes pills called thiazolidinediones or “TZDs” with Afrezza® may cause heart failure in some people. This can happen even if you have never had heart failure or heart problems before. If you already have heart failure it may get worse while you take TZDs with Afrezza®. Your healthcare provider should monitor you closely while you are taking TZDs with Afrezza®. Tell your healthcare provider if you have any new or worse symptoms of heart failure including:
    • Shortness of breath, swelling of your ankles or feet, sudden weight gain.

Treatment with TZDs and Afrezza® may need to be changed or stopped by your healthcare provider if you have new or worse heart failure.

Get emergency medical help if you have:

  • • Trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, confusion.

The most common side effects of Afrezza® include:

  • • Low blood sugar (hypoglycemia), cough, sore throat

These are not all the possible side effects of Afrezza®.Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088).

WHAT ARE THE INGREDIENTS IN AFREZZA®?

Active ingredient: human insulin
Inactive ingredients: fumaryl diketopiperazine, polysorbate 80

Prescribing Information | Medication Guide

FAQs

WHAT IS AFREZZA®?

• Afrezza® is a man-made insulin that is breathed-in through your lungs (inhaled) and is used to control high blood sugar in adults with diabetes mellitus.
• Afrezza® is not for use in place of long-acting insulin. Afrezza® must be used with long-acting insulin in people who have type 1 diabetes mellitus.
• Afrezza® is not for use to treat diabetic ketoacidosis.
• It is not known if Afrezza® is safe and effective for use in people who smoke. Afrezza® is not for use in people who smoke or have recently stopped smoking (less than 6 months).
• It is not known if Afrezza® is safe and effective in children under 18 years of age.

HOW IS AFREZZA® DIFFERENT FROM OTHER INSULINS?

Afrezza® is unique because it is the only ultra rapid-acting inhaled insulin available. It starts working quickly without the need for injections at mealtime. Once you breathe Afrezza® into your lungs using the inhaler, insulin appears in your bloodstream in less than 1 minute and it starts controlling blood sugar in about 12 minutes. Afrezza® stops lowering blood glucose after 1.5 to 3 hours, depending on the dose.*

*for the 4-unit and 12-unit cartridges, respectively.

WILL AFREZZA® REPLACE MY CURRENT LONG-ACTING INSULIN?

If you have type 1 diabetes, you will still need to take a long-acting insulin, or use an insulin pump for your basal needs depending on what you and your healthcare provider decide. Your healthcare provider may prescribe Afrezza® to treat mealtime spikes in blood sugar. If you are living with type 2 diabetes, your healthcare provider may consider adjustments to your other diabetes medications if they prescribe Afrezza®.

CAN I TAKE AFREZZA® WITH DIABETES PILLS?

Afrezza® can be taken with oral diabetes medicines. Be sure to tell your healthcare provider about all other medicines and supplements you are taking because they can affect the way your insulin works.

WHO SHOULD NOT USE AFREZZA®?

Do not use Afrezza® if you:
• Have chronic lung problems such as asthma or COPD.
• Are allergic to regular human insulin or any of the ingredients in Afrezza®. See the end of this Medication Guide for a complete list of ingredients in Afrezza®.

WHAT SHOULD I TELL MY HEALTHCARE PROVIDER BEFORE USING AFREZZA®?

Before using Afrezza®, tell your healthcare provider about all your medical conditions, including if you:
• Have lung problems such as asthma or COPD
• Have or have had lung cancer
• Are using any inhaled medications
• Smoke or have recently stopped smoking
• Have kidney or liver problems
• Are pregnant, planning to become pregnant, or are breastfeeding. Afrezza® may harm your unborn or breastfeeding baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins or herbal supplements.
Before you start using Afrezza®, talk to your healthcare provider about low blood sugar and how to manage it.

WHAT ARE THE MOST COMMON SIDE EFFECTS OF AFREZZA®?

The most common side effects of Afrezza® include low blood sugar (hypoglycemia), cough, and sore throat or throat irritation.

COULD AFREZZA® AFFECT MY LUNGS?

Before prescribing Afrezza®, your healthcare provider will perform a breathing test to establish a baseline reading of your lung function. Your healthcare provider may test again at 6 months and once a year after that. As a reminder, if you have had or have asthma, COPD, or chronic lung disease, please tell your healthcare provider because patients with lung issues should not use Afrezza®. There is no proven link between Afrezza® and the risk of lung cancer.

HOW SHOULD I USE AFREZZA®?

• Read the detailed Instructions for Use that comes with your Afrezza®.
• Take Afrezza® exactly as your healthcare provider tells you to. Your healthcare provider should tell you how much Afrezza® to use and when to use it.
• Know the strength of Afrezza® you use. Do not change the amount of Afrezza® you use unless your healthcare provider tells you to.
• Take Afrezza® at the beginning of your meal.
Check your blood sugar levels. Ask your healthcare provider what your blood sugar should be and when you should check your blood sugar levels.
• Keep Afrezza® and all medicines out of the reach of children.

YOUR DOSE OF AFREZZA® MAY NEED TO CHANGE BECAUSE OF:

Change in level of physical activity or exercise, weight gain or loss, increased stress, illness, change in diet, or because of other medicines you take.

WHAT ARE THE INGREDIENTS IN AFREZZA®?

Active ingredient: human insulin

Inactive ingredients: fumaryl diketopiperazine, polysorbate 80

Contacts

Customer Service Hours:
Monday - Thursday 6:00am to 7:00pm
Friday 6:00am to 6:00pm
Saturday 8:00am to 4:00pm
Sunday 8:00am to 4:00pm
(Times displayed in Pacific Time)
Mail:

getafrezza
PO Box 6552
Scottsdale, AZ 85261
USA
Email:

Customer Support: service@GetAfrezza.com

Complaint Dept: complaints@GetAfrezza.com

Phone:

Toll Free Customer Support:

(877) 352-2005