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<div style="text-align: left;"> What is the most important information I should know about AFREZZA&reg;? AFREZZA&reg; can cause serious side effects, including... </div>

<div style="text-align: left;"> IMPORTANT SAFETY INFORMATION </div>

<div style="max-width: 800px; margin: 0 auto; padding: 20px; font-family: Arial, sans-serif; color: #000;"> <h2 style="margin-bottom: 10px;">What is the most important information I should know about AFREZZA&reg;?</h2> AFREZZA&reg; can cause serious side effects, including: Sudden lung problems (bronchospasms). In a study, some AFREZZA&reg;-treated patients with asthma, whose asthma medication was temporarily withheld, experienced sudden lung problems. Do not use AFREZZA&reg; if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting AFREZZA&reg;, your healthcare provider will give you a breathing test to check how your lungs are working. <h2 style="margin-bottom: 10px;">What is AFREZZA&reg;?</h2> <ul style="list-style-type: disc; padding-left: 20px; margin-bottom: 16px;"> <li>AFREZZA&reg; is a man-made insulin that is breathed-in through your lungs (inhaled) and is used to control high blood sugar in adults with diabetes mellitus.</li> <li>AFREZZA&reg; is not for use to treat diabetic ketoacidosis. AFREZZA&reg; must be used with basal insulin in people who have type 1 diabetes mellitus.</li> <li>It is not known if AFREZZA&reg; is safe and effective for use in people who smoke. AFREZZA&reg; is not for use in people who smoke or have recently stopped smoking (less than 6 months).</li> <li>It is not known if AFREZZA&reg; is safe and effective in children under 18 years of age.</li> </ul> <h2 style="margin-bottom: 10px;">Who should not use AFREZZA&reg;?</h2> Do not use AFREZZA&reg; if you: <ul style="list-style-type: disc; padding-left: 20px; margin-bottom: 16px;"> <li>Have chronic lung problems such as asthma or COPD.</li> <li>Are allergic to regular human insulin or any of the ingredients in AFREZZA&reg;. See the end of the <a href="https://afrezza.com/med-guide/" target="_blank" rel="noopener noreferrer">Medication Guide</a> for a complete list of ingredients in Afrezza&reg;.</li> <li>Are having an episode of low blood sugar (hypoglycemia).</li> </ul> <h2 style="margin-bottom: 10px;">What should I tell my healthcare provider before using AFREZZA&reg;?</h2> Before using AFREZZA&reg;, tell your healthcare provider about all your medical conditions, including if you: <ul style="list-style-type: disc; padding-left: 20px; margin-bottom: 16px;"> <li>Have lung problems such as asthma or COPD</li> <li>Have or have had lung cancer</li> <li>Are using any inhaled medications</li> <li>Smoke or have recently stopped smoking</li> <li>Have kidney or liver problems</li> <li>Are pregnant, planning to become pregnant, or are breastfeeding. AFREZZA&reg; may harm your unborn or breastfeeding baby.</li> </ul> Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins or herbal supplements. Before you start using AFREZZA&reg;, talk to your healthcare provider about low blood sugar and how to manage it. <h2 style="margin-bottom: 10px;">What should I avoid while using AFREZZA&reg;?</h2> While using AFREZZA&reg; do not: <ul style="list-style-type: disc; padding-left: 20px; margin-bottom: 16px;"> <li>Drive or operate heavy machinery, until you know how AFREZZA&reg; affects you</li> <li>Drink alcohol or use over-the-counter medicines that contain alcohol</li> <li>Smoke</li> </ul> <h2 style="margin-bottom: 10px;">What are the possible side effects of AFREZZA&reg;?</h2> AFREZZA&reg; may cause serious side effects that can lead to death, including: See “What is the most important information I should know about AFREZZA&reg;?” Low blood sugar (hypoglycemia). Signs and symptoms that may indicate low blood sugar include: <ul style="list-style-type: disc; padding-left: 20px; margin-bottom: 16px;"> <li>Dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability or mood change, hunger.</li> </ul> Decreased lung function. Your healthcare provider should check how your lungs are working before you start using AFREZZA&reg;, 6 months after you start using it, and yearly after that. Lung cancer. In studies of AFREZZA&reg; in people with diabetes, lung cancer occurred in a few more people who were taking AFREZZA&reg; than in people who were taking other diabetes medications. There were too few cases to know if lung cancer was related to AFREZZA&reg;. If you have lung cancer, you and your healthcare provider should decide if you should use AFREZZA&reg;. Diabetic ketoacidosis. Talk to your healthcare provider if you have an illness. Your AFREZZA&reg; dose or how often you check your blood sugar may need to be changed. Severe allergic reaction (whole body reaction). Get medical help right away if you have any of these signs or symptoms of a severe allergic reaction: <ul style="list-style-type: disc; padding-left: 20px; margin-bottom: 16px;"> <li>A rash over your whole body, trouble breathing, a fast heartbeat, or sweating.</li> </ul> Low potassium in your blood (hypokalemia). Heart failure. Taking certain diabetes pills called thiazolidinediones or “TZDs” with AFREZZA&reg; may cause heart failure in some people. This can happen even if you have never had heart failure or heart problems before. If you already have heart failure it may get worse while you take TZDs with AFREZZA&reg;. Your healthcare provider should monitor you closely while you are taking TZDs with AFREZZA&reg;. Tell your healthcare provider if you have any new or worse symptoms of heart failure including: <ul style="list-style-type: disc; padding-left: 20px; margin-bottom: 16px;"> <li>Shortness of breath, swelling of your ankles or feet, sudden weight gain.</li> </ul> Treatment with TZDs and AFREZZA&reg; may need to be changed or stopped by your healthcare provider if you have new or worse heart failure. Get emergency medical help if you have: <ul style="list-style-type: disc; padding-left: 20px; margin-bottom: 16px;"> <li>Trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, confusion.</li> </ul> The most common side effects of AFREZZA&reg; include: <ul style="list-style-type: disc; padding-left: 20px; margin-bottom: 16px;"> <li>Low blood sugar (hypoglycemia), cough, sore throat.</li> </ul> These are not all the possible side effects of AFREZZA&reg;. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit <a href="https://www.fda.gov/medwatch" target="_blank" rel="noopener">www.fda.gov/medwatch</a>, or call 1-800-FDA-1088 (1-800-332-1088). <h2 style="margin-bottom: 10px;">WHAT ARE THE INGREDIENTS IN AFREZZA&reg;?</h2> Active ingredient: human insulin Inactive ingredients: fumaryl diketopiperazine, polysorbate 80 <a style="color: #484bf3;" href="https://afrezza.com/wp-content/uploads/2023/02/Full-Prescribing-Information-Feb-2023-1.pdf" target="_blank" rel="noopener">Prescribing Information</a> | <a style="color: #484bf3;" href="https://afrezza.com/med-guide/" target="_blank" rel="noopener">Medication Guide</a> US-AFR-2681 </div> Footnotes *This offer is not valid for patients receiving prescription reimbursement under any federal-, state-, or government-funded healthcare program, such as Medicare, Medicare Advantage, Medicare Part D, Medicaid, Medigap, Veterans Affairs (VA), the Department of Defense (DOD), or TRICARE, or where prohibited by law. Maximum benefit limitations and other restrictions apply. Click <a href="https://afrezza.com/savings-program/" target="_blank" style="text-decoration: underline;">here</a> for complete program terms and conditions. **The Direct Purchase Program is applicable for commercially insured patients whose prior authorization has been denied. 3-box maximum, $99 per box. For more information, please contact our patient support team at Afrezza® Assist 1-844-323-7399, Monday-Friday 8am-8pm ET.

Important Safety Information

Afrezza® is a man-made insulin that is breathed-in through your lungs (inhaled) and is used to control high blood sugar in adults with diabetes mellitus.

What is Afrezza®?

Inhale your insulin right when food arrives, and Afrezza® will start lowering your blood sugar in about 12 minutes.
By inhaling your insulin, you can save up to 1,000 needlesticks per year.*
*Based on an estimation of approximately 3 meals per day, for a total of 1,095 possible mealtime injections per year.

No planning. No waiting. No needlesticks.

Afrezza® is a needle-free mealtime insulin for people living with type 1 or type 2 diabetes.
Talk to a doctor to see if Afrezza® may be right for you.

Discover management in the moment.

Afrezza® is available in 4-, 8-, and 12-unit color-coded cartridges. The insulin is breathed-in through your lungs using the oral inhaler.
Delivering the insulin over the large surface area of the lungs allows for ultra-rapid absorption.

Why inhale your insulin?

Once inhaled, Afrezza® starts lowering your blood sugar in about 12 minutes, and stops lowering your blood sugar in 1.5 &#8211; 3 hours.*
This gives you the flexibility to inhale your insulin when you are ready to eat, so you can be spontaneous and still in control.
*For the 4-unit and 12-unit cartridges, respectively.

Fast in. Fast out. Fits your lifestyle.

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MANN_AFR_SUM22_WhiteScreen-Product_1497

If you're struggling with blood sugar control at mealtime and interested in a different option, you're in the right place!

Afrezza® (insulin human) Inhalation Powder

<div style="font-size: 12px; line-height: 1.5;"> Afrezza® is a man-made insulin that is breathed-in through your lungs (inhaled) and is used to control high blood sugar in adults with diabetes mellitus. Important Safety Information: AFREZZA can cause serious side effects, including: Sudden lung problems (bronchospasms). In a study, some AFREZZA-treated patients with asthma, whose asthma medication was temporarily withheld, experienced sudden lung problems. Do not use AFREZZA if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting AFREZZA, your healthcare provider will give you a breathing test to check how your lungs are working. Please see Important Safety Information, including BOXED WARNING for AFREZZA below. Click to view the <a href="https://afrezza.com/wp-content/uploads/2023/02/Full-Prescribing-Information-Feb-2023-1.pdf" target="_blank" style="text-decoration: underline;">Full Prescribing Information</a>, <a href="https://afrezza.com/wp-content/uploads/2023/02/Medication-Guide-Feb-2023.pdf" target="_blank" style="text-decoration: underline;">Medication Guide</a> and <a href="https://afrezza.com/wp-content/uploads/2023/03/Instructions-for-Use-Feb-2023.pdf" target="_blank" style="text-decoration: underline;">Instructions for Use</a> for Afrezza. What to expect: Pay just $25 to talk to one of our doctors, licensed in your state, to determine if Afrezza® is right for you. You and the doctor will evaluate how Afrezza® fits into your current diabetes treatment plan. If Afrezza® is prescribed, with the Afrezza® Savings Card, eligible commercially insured patients may pay as little as $35 per month.* If your insurance doesn’t cover Afrezza®, MannKind also offers a Direct Purchase Program. You may be eligible to get Afrezza® for as little as ~$3 per day for a 30-day supply.** Medicare Part D recipients can obtain Afrezza® for a copay of no more than $35 a month if covered by their health plan. There will be no deductible for covered insulin products. Coverage may require Afrezza® approval with a prior authorization or appeal. </div>

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